Long-Term Benefit of Early Pre-Reperfusion Metoprolol Administration in Patients With Acute Myocardial Infarction

Long-Term Benefit of Early Pre-Reperfusion Metoprolol Administration in Patients With Acute Myocardial Infarction Results From the METOCARD-CNIC Trial (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction) Gonzalo Pizarro, MD,*y Leticia Fernández-Friera, MD, PHD,*z Valentin Fuster, MD, PHD,*x Rodrigo Fernández-Jiménez, MD,*k José M. García-Ruiz, MD,*{ Ana García-Álvarez, MD, PHD,*# Alonso Mateos, MD,** María V. Barreiro, MD,yy Noemí Escalera, BPT,* Maite D. Rodriguez, RN,* Antonio de Miguel, MD,zz Inés García-Lunar, MD,*yxx Juan J. Parra-Fuertes, MD,kk Javier Sánchez-González, PHD,*{{ Luis Pardillos, MD,** Beatriz Nieto, MD,zzAdriana Jiménez, MD,## Raquel Abejón, RN,** Teresa Bastante, MD,*** Vicente Martínez de Vega, MD,y José A. Cabrera, MD, PHD,y Beatriz López-Melgar, MD,*kk Gabriela Guzman, MD, PHD,*yyy Jaime García-Prieto, BSC,* Jesús G. Mirelis, MD, PHD,*xx José Luis Zamorano, MD, PHD,k Agustín Albarrán, MD, PHD,kk Javier Goicolea, MD, PHD,xx Javier Escaned, MD, PHD,*k Stuart Pocock, PHD,*zzz Andrés Iñiguez, MD, PHD,zz Antonio Fernández-Ortiz, MD, PHD,*k Vicente Sánchez-Brunete, MD,** Carlos Macaya, MD, PHD,k Borja Ibanez, MD, PHD*k Madrid, Oviedo, Barcelona, Galicia, Pontevedra, and León, Spain; New York, New York; and London, United Kingdom